Belgian College of Neuropsychopharmacology and Biological Psychiatry 

Ilse Smolders


1/ Full-length papers in PubMed-cited international peer-reviewed journals


- Van Liefferinge J, Massie A, Portelli J, Di Giovanni G, Smolders I.
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Front Cell Neurosci. 2013 Aug 30;7:139. Review.
SCI Impactfactor  2012 = 4.469.

- Loyens E, De Bundel D, Demaegdt H, Chai SY, Vanderheyden P, Michotte Y, Gard P, Smolders I.
Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase
Int J Neuropsychopharmacol. 16 (2013) 1153-1163.
SCI Impactfactor  2012 = 5.641.

- Gómez-Galán M, De Bundel D, Van Eeckhaut A, Smolders I, Lindskog M.
Dysfunctional astrocytic regulation of glutamate transmission in a rat model of depression.
Molecular Psychiatry. 18 (2013) 582-594.
SCI Impactfactor 2012 = 14.897.

- Afrikanova T, Serruys AS, Buenafe OE, Clinckers R, Smolders I, de Witte PA, Crawford AD, Esguerra CV.
Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.
PLoS One. 2013;8(1):e54166. doi: 10.1371/journal.pone.0054166. Epub 2013 Jan 14.
SCI Impactfactor  2012 = 3.730.

- Schallier A, Vermoesen K, Loyens E, Van Liefferinge J, Michotte Y, Smolders I, Massie A.
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Nutr Neurosci. 16 (2013):78-82.
SCI Impactfactor  2012 = 1.647.

- Burguière A, De Bundel D, Valjent E, Roger J, Smolders I, Fagni L, Perroy J.
Combination of group I mGlu receptors antagonist with dopaminergic agonists strengthens the synaptic transmission at corticostriatal synapses in culture.
Neuropharmacology. 66 (2013) 151-157.
SCI Impactfactor  2012 = 4.114.

- Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P.
The Cystine/Glutamate Antiporter System xc- in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities. Review.
Antioxid Redox Signal. 18 (2013) 522-555.
SCI Impactfactor  2012 = 7.189.

- Brouwers S, Smolders I, Massie A, Dupont AG.
Angiotensin II Type 2 Receptor-Mediated and Nitric Oxide-Dependent Renal Vasodilator Response to Compound 21 Unmasked by Angiotensin-Converting Enzyme Inhibition in Spontaneously Hypertensive Rats In Vivo.
Hypertension. 62 (2013) 920-926
SCI Impactfactor 2012 = 6.873

- Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA, Smolders I.
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Neurotherapeutics 9 (2012) 658-672.
SCI Impactfactor  = 5.904.

- Portelli J, Michotte Y, Smolders I.
Ghrelin: An emerging new anticonvulsant neuropeptide. Review.
Epilepsia. 53 (2012) 585-595.
SCI Impactfactor = 3.909.

- Vermoesen K, Massie A, Smolders I, Clinckers R.
The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy.
Epilepsia. 53 (2012) 870-878
SCI Impactfactor  = 3.909.

- Loyens E, Vermoesen K, Schallier A, Michotte Y, Smolders I.
Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors.
Brain Res. 1436 (2012) 43-50.
SCI Impactfactor = 2.879.

- Meurs A, Portelli J, Clinckers R, Balasubramaniam A, Michotte Y, Smolders I.
Neuropeptide Y increases in vivo hippocampal extracellular glutamate levels through Y1 receptor activation.
Neurosci Lett. 510 (2012) 143-147.
SCI Impactfactor = 2.026.

- Caljon G, Caveliers V, Lahoutte T, Stijlemans B, Ghassabeh G, Van Den Abbeele J, Smolders I, De Baetselier P, Michotte Y, Muyldermans S, Magez S, Clinckers R.
Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier.
Br J Pharmacol. 165 (2012) 2341-2353.
SCI Impactfactor = 5.069.


- D. De Bundel, A. Schallier, E. Loyens, R. Fernando, H. Miyashita, K. Vermoesen, J. Van Liefferinge, S. Bannai, H. Sato, Y. Michotte, I. Smolders#, A. Massie# (#equally contributing senior authors)
Loss of system xc- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.
J. Neurosci. 31 (2011) 5792-5803.
SCI impactfactor = 7.115

- N. Aourz, D. De Bundel, B. Stragier, R. Clinckers, J. Portelli, Y. Michotte, I. Smolders.
Rat hippocampal somatostatin sst(3) and sst(4) receptors mediate anticonvulsive effects in vivo: Indications of functional interactions with sst(2) receptors.
Neuropharmacology. 61 (2011) 1327-1333.
SCI impactfactor = 4.814

- E. Loyens, A. Schallier, S.Y. Chai, D. De Bundel, P. Vanderheyden, Y. Michotte, I. Smolders.
Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures.
Seizure. 20 (2011) 602-605
SCI impactfactor = 1.798

- K. Vermoesen, A.S. Serruys, E. Loyens, T. Afrikanova, A. Massie, A. Schallier, Y. Michotte, A.D.  Crawford, C.V. Esguerra, P.A. de Witte, I. Smolders, R. Clinckers.
Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.
Epilepsy Behav. 22 (2011) 450-460.
SCI impactfactor = 2.335

- R. Raedt, R. Clinckers, L. Mollet, K. Vonck, R. El Tahry, T. Wyckhuys, V. De Herdt, E. Carrette, W. Wadman, Michotte Y, Smolders I, Boon P, Meurs A.
Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation (VNS) in a limbic seizure model.
J Neurochem.  57 (2011) 956-964.
SCI impactfactor = 4.061

- A. Schallier, I. Smolders, D. Van Dam, E. Loyens, P.P. De Deyn, A. Michotte, Y. Michotte, A. Massie. Region- and age-specific changes in glutamate transport in the APP23 mouse model for Alzheimer’s disease.
J Alzheimers Dis  24 (2011) 287-300.
SCI impactfactor = 3.745

- A. Van Eeckhaut, K. Maes, N. Aourz, I. Smolders, Y. Michotte
The absolute quantification of endogenous levels of brain neuropeptides in vivo using LC–MS/MS
Bioanalysis 3 (2011) 1271-1285.
SCI impactfactor = 3.223

- C. Meissirel, C. Ruiz de Almodovar, E. Knevels, C. Coulon, N. Chounlamountri, I. Segura, P. de Rossi, S. Vinckier, K. Anthonis, B. Deléglise, M. de Mol, C. Ali, K. Dassonville, E. Loyens, J. Honnorat, Y. Michotte, V. Rogemond, I. Smolders, T. Voets, D. Vivien, P. Vanden Berghe, L. Van den Bosch, W. Robberecht, A. Chédotal, S. Oliviero, M. Dewerchin, D. Schmucker, N. Thomasset, P. Salin, P. Carmeliet.
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
Proc Natl Acad Sci U S A. 108 (2011) 13782-13787.
SCI impactfactor = 9.681

- A. Massie, A. Schallier, K. Seong-Woong, H. Beck, D. De Bundel, K. Vermoesen, S. Bannai, I. Smolders, M. Conrad, N. Plesnila, H. Sato, Y. Michotte.
Dopaminergic neurons of system xc- deficient mice are protected against 6-OHDA induced neurodegeneration.
FASEB J  25 (2011) 1359-1369.
SCI impactfactor = 5.712

- R. Yang, I. Smolders, P. Vanderheyden, H. Demaegdt, A. Van Eeckhaut, G. Vauquelin, A. Lukaszuk, D. Tourwé, S.Y. Chai, A.L. Albiston, C. Nahmias, T. Walther, A.G. Dupont
Pressor and renal hemodynamic effects of the novel angiotensin A peptide are AT1a receptor dependent
Hypertension  57 (2011) 956-664.
SCI impactfactor = 6.207

- R. Yang, I. Smolders, A.G. Dupont.
Blood pressure and renal hemodynamic effects of angiotensin fragments. Review.
Hypertension Res  34 (2011) 674-683.
SCI impactfactor = 2.576


- Clinckers R, Zgavc T, Vermoesen K, Meurs A, Michotte Y, Smolders I.
Pharmacological and neurochemical characterization of the involvement of hippocampal adrenoreceptor subtypes in the modulation of acute limbic seizures.
J Neurochem. 115 (2010) 1595-607.
5-year SCI impactfactor = 4.206

- Vermoesen K, Smolders I, Massie A, Michotte Y, Clinckers R.
The control of kainic acid-induced status epilepticus.
Epilepsy Res. 90 (2010) 164-6.
5-year SCI impactfactor = 2.669

- D. De Bundel, N. Aourz, F. Kiagiadaki, R. Clinckers, D. Hoyer, A. Kastellakis, Y. Michotte, K. Thermos, I. Smolders.
Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats.
NeuroReport 21 (2010) 254-258.
5-year SCI impactfactor 2008 = 2.260

- D. De Bundel, H. Demaegdt, T. Lahoutte, V. Caveliers, K. Kersemans; A.G. Ceulemans, G. Vauquelin, R. Clinckers, P. Vanderheyden, Y. Michotte, I. Smolders.
Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory.
J Neurochem. 112 (2010) 1223-1234.
5-year SCI impactfactor = 4.206

- G. Laureys, R. Clinckers, S. Gerlo, A. Spooren, N. Wilczak, R. Kooijman, I. Smolders, Y. Michotte, J. De Keyser.
Astrocytic beta(2)-adrenergic receptors: From physiology to pathology. Review.
Prog Neurobiol. 91 (2010) 189-99.
5-year SCI impactfactor  = 11.554

- R. Yang, T. Walther, F. Gembardt, I. Smolders, P. Vanderheyden, A.L. Albiston, S.Y. Chai, A.G. Dupont.
Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated.
J Hypertens. 28 (2010) 487-494.
5-year SCI impactfactor = 4.487

- B. Bosier, S. Sarre, I. Smolders, Y. Michotte, E. Hermans,D.M. Lambert.
Revisiting the complex influences of cannabinoids on motor functions unravels pharmacodynamic differences between cannabinoid agonists.
Neuropharmacology. 59 (2010) 503-10.
5-year SCI impactfactor = 3.824

- A. Schallier, A. Massie, E. Loyens, D. Moechars, Y. Michotte & I. Smolders.
VGLUT2 heterozygous mice are more susceptible to pentylenetetrazole-induced seizures.
Neurochem. Int. 55 (2009) 41-44.  
SCI impactfactor = 3.541

- J. Portelli, N. Aourz, D. De Bundel, A. Meurs, I. Smolders, Y. Michotte, R. Clinckers.
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.
Epilepsy Res. 87 (2009) 234-246.
SCI impactfactor = 2.479

- R. Clinckers, I. Smolders, K. Vermoesen, Y. Michotte, M. Danhof, R. Voskuyl, O. Della Pasqua.
Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.
Expert Opin Drug Metab Toxicol. 5 (2009) 1267-1277. Review.
SCI impactfactor = 3.076

- D. De Bundel, I. Smolders, A.L. Albiston, Y. Michotte & S.Y. Chai.
IRAP inhibitors enhance spatial working memory: effects on extracellular hippocampal glucose levels.
Neurobiol Learn Mem. 92 (2009) 19-26.
SCI impactFactor  = 3.479

- A. Van Eeckhaut, K. Lanckmans, S. Sarre, I. Smolders & Y. Michotte.
Validation of bioanalytical LC-MS/MS assays: Evaluation of matrix effects.
J Chromatogr B Analyt Technol Biomed Life Sci. 877 (2009) 2198-2207. Review.
SCI impactfactor  = 2.777

- V. Umbrain, MH. Lauwers, L. Shi, I. Smolders, Y. Michotte & J. Poelaert.  
Comparison of the effects of intrathecal administration of levobupivacaine and lidocaine on the prostaglandin E2 and glutamate increases in cerebrospinal fluid: a microdialysis study in freely moving rats.
Br J Anaesth. 102 (2009) 540-5.
SCI impactfactor = 3.827
- V. Umbrain, I. Smolders, J. Poelaert.
Is Intrathecal lidocaine administration risk-free in rats with neuropathic pain? Reply to [Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain 13 (2009) 130-137].
Eur J Pain. 13 (2009) 890; author reply 891.
SCI impactfactor = 3.612

- A.G. Dupont, R. Yang, I. Smolders & P. Vanderheyden.
IRAP and AT(1) receptor mediated effects of angiotensin IV.
J Intern Med. 265 (2009) 401-103; letter to the editor.
SCI impactfactor = 5.942

- I. Smolders, R. Clinckers, A. Meurs, D. De Bundel, J. Portelli, G. Ebinger & Y. Michotte.
Hippocampal dopamine and serotonin as potential biomarkers for predicting combined antidepressant-anticonvulsant action of ionotropic and metabotropic glutamate receptor ligands
Neuropharmacology 54 (2008) 1017-1028.
SCI impactfactor = 3.383

- R. Clinckers, I. Smolders, Y. Michotte, G. Ebinger, R. Voskuyl, M. Danhof & O. Della Pasqua.
Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain.
Brit. J. Pharmacol. 155 (2008) 1127-1138.
SCI impactfactor = 4.902

- A. Meurs, R. Clinckers, G. Ebinger, Y. Michotte & I. Smolders.
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Epilepsy Res. 78 (2008) 50-59.
SCI impactfactor = 2.405

- D. De Bundel, S. Sarre, A. Van Eeckhaut, I. Smolders & Y. Michotte.
Critical evaluation of acetylcholine determination in rat brain microdialysates using ion-pair liquid chromatography with amperometric detection
Sensors 8 (2008) 5171-5185.
SCI impactfactor = 1.870

- D. De Bundel, I. Smolders, P. Vanderheyden & Y. Michotte.
 Ang II and Ang IV: Effects on synaptic plasticity, learning, memory, seizures and epilepsy.
CNS Neurosci. Ther. 14 (2008) 315-339. Review
SCI impactfactor= 3.795

- R. Yang, I. Smolders, D. De Bundel, R. Fouyn, H. Demaeghdt, P. Vanderheyden & A.G. Dupont.
Brain and peripheral AT1 receptors mediate renal vasoconstrictor and blood pressure responses to angiotensin IV in the rat.
J. Hypertens. 26 (2008) 998-1007.
SCI impactfactor = 5.132

- A. Massie, A. Schallier, B. Mertens, K. Vermoesen, S. Bannai, H. Sato, I. Smolders & Y. Michotte.
Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats.
Neuroreport 19 (2008) 1589-1592.
SCI impactfactor = 1.904

- A. Massie, L. Cnops, I. Smolders, R. McCullumsmith, R. Kooijman, S. Kwak, L. Arckens & Y. Michotte.
High-affinity Na+/K+-dependent glutamate transporter EAAT4 is expressed throughout the rat fore- and midbrain.
J Comp Neurol. 511 (2008) 155-172.
SCI impactfactor = 3.743

- K. Lanckmans, S. Sarre, I. Smolders & Y. Michotte.
Quantitative LC-MS for the analysis of microdialysates. Review.
Talanta 74 (2008) 458-469.
SCI impact factor = 3.206

- V. Umbrain, L. Shi, MH. Lauwers, I. Smolders, Y. Michotte & F. Camu.
Intrathecal lidocaine elevates prostaglandin E2 levels in cerebrospinal fluid: a microdialysis study in freely moving rats.
Br J Anaesth. 101 (2008) 716-722.
SCI impact factor = 2.920

- B. Stragier, D. De Bundel, S. Sarre, I. Smolders, G. Vauquelin, A.G. Dupont, Y. Michotte & P. Vanderheyden.
Involvement of insulin-regulated aminopeptidase in the effects of the renin-angiotensin fragment angiotensin IV. Invited review.
Heart Fail. Rev. 13 (2008) 321-337.
SCI impactfactor = 4.015


- A. Meurs, R. Clinckers, G. Ebinger, Y. Michotte & I. Smolders.
Sigma 1 Receptor-Mediated Increase in Hippocampal Extracellular Dopamine Contributes to the Anticonvulsant Mechanism of Action of Neuropeptide Y.
Eur. J. Neurosci. 26 (2007) 3079-3092
SCI impactfactor= 3.673

- A. Meurs, R. Clinckers, G. Ebinger, Y. Michotte & I. Smolders.
Clinical Potential of Neuropeptide Y Receptor Ligands in the Treatment of Epilepsy. Invited Review.
Curr. Top. Med.Chem. 7 (2007) 1660-74
SCI impact factor = 4.325

- K. Lanckmans, B. Stragier, S. Sarre, I. Smolders & Y. Michotte.
Nano-LC-MS/MS for the monitoring of angiotensin IV in rat brain microdialysates: Limitations and possibilities.
J. Sep. Sci. 30 (2007) 2217-2224.
SCI impact factor = 2.632

- B. Stragier, H. Demaegdt, D. De Bundel, I. Smolders, S. Sarre, G. Vauquelin, G. Ebinger, Y. Michotte & P. Vanderheyden.
Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat.
Brain Res. 1131 (2007) 97-105
SCI impact factor = 2.218
- K. Lanckmans, S. Sarre, I. Smolders & Y. Michotte.
Use of a structural analogue versus a stable isotopically labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano liquid chromatography-tandem mass spectrometry.*
Rapid Comm Mass Spectrom 21 (2007) 1187-1195
SCI impact factor  = 2.971

- A. Meurs, R. Clinckers, G. Ebinger, Y. Michotte & I. Smolders.
Not Hippocampus but Substantia Nigra is an Anticonvulsant Site of Action of Topiramate in the Focal Pilocarpine Model of Limbic Seizures.
Epilepsia 47 (2006) 1519-1535
SCI impactfactor = 3.526
- K. Lanckmans, A. Van Eeckhaut, S. Sarre, I. Smolders & Y. Michotte.
Capillary and nano liquid chromatography-tandem mass spectrometry for the quantification of small molecules in microdialysis samples: comparison with microbore dimensions.
J. Chomatogr. A 1131 (2006) 166-175
SCI impactfactor = 3.554
- B. Stragier, R. Clinckers, A. Meurs, D. De Bundel, S. Sarre, G. Ebinger, Y. Michotte & I. Smolders.
Involvement of the somatostatin-2 receptor in the anticonvulsant effect of Ang IV against pilocarpine-induced limbic seizures in rats.
J. Neurochem. 98 (2006) 1100-1113
SCI impactfactor = 4.260
- L. Shi, I. Smolders, V. Umbrain, M.H. Lauwers, S. Sarre, Y. Michotte, M. Zizi & F. Camu.
Peripheral inflammation modifies the effect of intrathecal IL-1 on spinal PGE2 production mainly through cyclooxygenase (COX)-2 activity. A spinal microdialysis study in freely moving rats.
Pain  120 (2006) 307-314
SCI impactfactor = 4.836
- K. Lanckmans, R. Clinckers, A. Van Eeckhaut, S. Sarre, I. Smolders & Y. Michotte.
Use of microbore LC-MS/MS for the quantification of oxcarbazepine and its active metabolite in rat brain microdialysis samples.
J. Chomatogr. B Analyt. Technol.Biomed. Life Sci. 831 (2006) 205-212
SCI impactfactor = 2.647
- W. Chen, K. Kerckhofs, M. Van de Casteele, I. Smolders, D. Pipeleers, L. Zhidong.
Glucose inhibits GABA release by pancreatic beta cells through an increase in GABA shunt activity.
Am. J. Physiol. Endocrinol. Metabol. 290 (2006) E494-E499
SCI impactfactor = 4.123


- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger & Y. Michotte.
Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine.
Neurosci. Lett. 390 (2005) 48-53
SCI impactfactor = 1.898

- R. Clinckers, S. Gheuens, I. Smolders, A. Meurs, G. Ebinger & Y. Michotte.
In vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin.
Epilepsia 46 (2005) 828-836
SCI impactfactor = 3.227

- A. Van Hemelrijck, S. Sarre, I. Smolders & Y. Michotte.
Determination of amino acids associated with cerebral ischaemia in rat brain microdialysates using narrowbore liquid chromatography and fluorescence detection.
J. Neurosci. Meth. 144 (2005) 63-71
SCI impactfactor = 1.784

- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger & Y. Michotte.
Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity.
J. Pharmacol. Exp. Ther. 314 (2005) 725-731
SCI impactfactor = 4.098


- I. Smolders, H. Lindekens, R. Clinckers, A. Meurs, M.J. O’Neill, D. Lodge, G. Ebinger & Y.  Michotte.
In vivo modulation of extracellular glutamate and GABA levels and of limbic seizures by group I and II metabotropic glutamate receptor ligands.
J. Neurochem. 88 (2004) 1068-1077
SCI impactfactor = 4.824

- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger & Y. Michotte.
Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures.  
Neuropharmacology 47 (2004) 1053-1061
SCI impactfactor = 3.734

- S. Hachimi-Idrissi, A. Van Hemelrijck, A. Michotte, I. Smolders, S. Sarre, G. Ebinger, L. Huyghens & Y. Michotte.
Postischemic mild hypothermia reduces neurotransmitter release and astroglial cell proliferation during reperfusion after asphyxial cardiac arrest in rats.
Brain Res. 1019 (2004) 217-225
SCI impactfactor = 2.389

- R. Clinckers, I. Smolders, A. Meurs, G. Ebinger & Y. Michotte.
Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D2 and 5-HT1A receptors.
J. Neurochem. 89 (2004) 834-843
SCI impactfactor = 4.824

- A. Massie, L. Cnops, I. Smolders, K. Van Damme, E. Vandenbussche, F. Vandesande, U. Eysel & L. Arckens.
Extracellular GABA concentrations in area 17 of cat visual cortex during topographic map reorganization following binocular central retinal lesioning.
Brain Res. 976 (2003) 100-108
SCI impactfactor 2002 = 2.409

- I. Smolders, Z.A. Bortolotto, V.R.J. Clarke, R. Warre, G.M. Khan, M.J. O’Neill, P.L. Ornstein, D. Bleakman, A.M. Ogden, B. Weiss, J.P. Stables, K.H. Ho, G. Ebinger, G.L. Collingridge, D. Lodge & Y. Michotte.
Antagonists of GLUK5-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Nature Neurosci. 5 (2002) 796-804
SCI impactfactor  = 14.857

- G. Vauquelin, Y. Michotte, I. Smolders, S. Sarre, G. Ebinger, A. Dupont & P. Vanderheyden.
Editorial review: Cellular targets for angiotensin II fragments: pharmacological and molecular evidence.
JRAAS  3 (2002) 195-204.
SCI impactfactor 2005 = 1.169

 - I. Smolders, C. Gousseau, S. Marchand, W. Couet, G. Ebinger & Y. Michotte.
Convulsant and subconvulsant doses of norfloxacin in the presence and absence of biphenylacetic acid alter extracellular hippocampal glutamate but not GABA levels in conscious rats.
Antimicrob. Agents Chemother. 46 (2002) 471-477
SCI impactfactor  = 4.215


- I. Smolders, J. Van Loo, S. Sarre, G. Ebinger & Y. Michotte.
Effects of dietary sucrose on hippocampal serotonin release: a microdialysis study in the freely moving rat.
Br. J. Nutr. 86 (2001) 151-155
SCI impactfactor = 1.989

- G.M. Khan, I. Smolders, G. Ebinger & Y. Michotte.
2-chloro-N6-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Neuropharmacology 40 (2001) 657-667
SCI impactfactor = 3.854

- L. Bogaert, M.J. O’Neill, J. Moonen, S. Sarre, I. Smolders, G. Ebinger & Y. Michotte.
The effects of LY393613, nimodipine and verapamil, in focal cerebral ischemia.
Eur. J. Pharmacol. 411 (2001) 71-83
SCI impactfactor = 2.164


- G.M. Khan, I. Smolders, G. Ebinger & Y. Michotte.
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow.
Eur. J. Pharmacol. 407 (2000) 139-144
SCI impactfactor = 2.047

- H. Lindekens, I. Smolders, G.M. Khan, M. Bialer, G. Ebinger & Y. Michotte.
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Pharm. Res. 17 (2000) 1408-1413
SCI impactfactor = 2.847

- L. Bogaert, D. Scheller, J. Moonen, S. Sarre, I. Smolders, G. Ebinger & Y. Michotte.
Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia.
Brain Res. 887 (2000) 266-275
SCI impactfactor = 2.302

- G.M. Khan, I. Smolders, G. Ebinger & Y. Michotte.
Anticonvulsant effect and neurotransmitter modulation of focal and systemic 2-chloroadenosine against the development of pilocarpine-induced seizures.
Neuropharmacology 39 (2000) 2418-2432
SCI impactfactor = 4.176

- Z.A. Bortolotto, V.R.J. Clarke, C.M. Delany, M.C.Parry, I. Smolders, M. Vignes, K.H. Ho, P. Miu, B.T. Brinton, R. Fantaske, A. Ogden, M. Gates, P.L. Ornstein, D. Lodge, D. Bleakman & G.L. Collingridge.
Kainate receptors are involved in synaptic plasticity.
Nature 402 (1999) 297-301
SCI impactfactor = 29.491

- G.M. Khan, I. Smolders, H. Lindekens, J. Manil, G. Ebinger & Y. Michotte.
Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats.
Eur. J. Pharmacol. 373 (1999) 153-161
SCI impactfactor = 2.047

- K. Thorré, S. Sarre, I. Smolders, G. Ebinger & Y. Michotte.
Dopaminergic regulation of serotonin release in the substantia nigra of the freely moving rat using microdialysis.
Brain Res. 796 (1998) 107-116
SCI impactfactor = 2.150

- R. Meeusen, I. Smolders, S. Sarre, K. De Meirleir, H. Keizer, M. Serneels, G. Ebinger & Y. Michotte.
Endurance training effects on striatal neurotransmitter release, an in vivo microdialysis study.
Acta Physiol. Scand. 159 (1997) 335-341
SCI impactfactor = 1.204

- S. Sarre, I. Smolders, K. Thorré, G. Ebinger & Y. Michotte.
Biotransformation of locally applied precursors of dopamine, serotonin and noradrenaline in striatum and hippocampus, a microdialysis study.
J. Neural Transm. 104 (1997) 1215-1228
S.C.I. impactfactor = 1.659

- I. Smolders, G.M. Khan, H. Lindekens, S. Prikken, C.A. Marvin, J. Manil, G. Ebinger & Y. Michotte.
Effectiveness of vigabatrin against focally evoked pilocarpine-induced seizures and concomitant changes in extracellular hippocampal and cerebellar glutamate, GABA and dopamine levels, a microdialysis-electrocorticography study in freely moving rats.
J. Pharmacol. Exp. Ther. 283 (1997) 1239-1248
SCI impactfactor = 3.227

- I. Smolders, G.M. Khan, J. Manil, G. Ebinger & Y. Michotte.
NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats using microdialysis.
Br. J. Pharmacol. 121 (1997) 1171-1179
SCI impactfactor = 3.619

- I. Smolders, L. Bogaert, G. Ebinger & Y. Michotte.
Muscarinic modulation of striatal dopamine, glutamate and GABA release, as measured with in vivo microdialysis.
J. Neurochem. 68 (1997) 1942-1948
SCI impactfactor = 4.234

- I. Smolders, K. Van Belle, G. Ebinger & Y. Michotte.
Hippocampal and cerebellar extracellular amino acid levels during pilocarpine-induced seizures in freely moving rats as measured by microdialysis.
Eur. J. Pharmacol. 319 (1997) 21-29
SCI impactfactor = 1.960


- I. Smolders, S. Sarre, C. Vanhaesendonck, G. Ebinger & Y. Michotte.
Extracellular striatal dopamine and glutamate after decortication and kainate receptor stimulation, as measured by microdialysis.
J. Neurochem., 66 (1996) 2373-2380
SCI impactfactor = 4.219


- I. Smolders, N. De Klippel, S. Sarre, G. Ebinger & Y. Michotte.
Tonic GABA-ergic modulation of striatal dopamine release studied by in vivo microdialysis in the freely moving rat.
Eur. J. Pharmacol., 284 (1995) 83-91
SCI impactfactor = 2.637

- I. Smolders, S. Sarre, G. Ebinger & Y. Michotte.
The analysis of excitatory, inhibitory and other amino acids in rat brain microdialysates using microbore liquid chromatography.
J. Neurosci. Meth., 57 (1995) 47-53
SCI impactfactor = 1.815

- S. Sarre, K. Van Belle, I. Smolders, G. Krieken & Y. Michotte.  
The use of microdialysis for the determination of plasma protein binding of drugs.
J. Pharm. Biomed. Anal., 10 (1992) 735-739
SCI impactfactor=0.840

2/ Chapters in books

- I. Smolders, S. Sarre, G. Ebinger & Y. Michotte.
Microbore liquid chromatography analysis of amino acid transmitters.
Chapter 15 in "Methods in Molecular Biology: Neurotransmitter Methods", volume 72, edited by R.C. Rayne, Humana Press Inc., Totowa, NJ, USA, 1997, pg 197-204.  

- S. Sarre, K. Thorré, I. Smolders & Y. Michotte.
Microbore liquid chromatography analysis of monoamine transmitters.
Chapter 14 in "Methods in Molecular Biology: Neurotransmitter Methods", volume 72, edited by R.C. Rayne, Humana Press Inc., Totowa, NJ, USA, 1997, pg 185-196.

- I. Smolders & Y. Michotte.
The use of microdialysis for the study of neurological disorders.
Chapter 5.3 in “Handbook of Microdialysis: Methods, Applications and Perspectives” (Series: Techniques in Behavioral Sciences and Neural Sciences, TBNS, Volume 16 ), edited by B.H.C. Westerink & T. Cremers, Elsevier Books, pg 435-453.


- I. Smolders, R. Clinckers & Y. Michotte
Microdialysis as a tool to unravel neurobiological mechanisms of seizures and antiepileptic drug action.
Chapter 4.5. in “Applications of Microdialysis in Pharmaceutical Science” edited by T.H. Tsai, John Wiley and Sons Inc., pg 207-253.

- I. Smolders, G. Laekeman.
Neurobiologische en psychofarmacologische basiskennis.
Hoofdstuk 2 in het handboek “Psychofarmacotherapie” uitgegeven door Academia Press in opdracht van the Belgian College of Neuropsychopharmacology and Biological Psychiarty, in press.



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